What is Ethyl Acetate Plant and Process Technology and Why Do We Use Them?

Ethyl Acetate Plant and Process Technology, Ethanol Dehydration ...

Ethyl Acetate Production Plant

Lung cancer, the second leading cause of cancer-related deaths, urgently requires new therapies due to rising drug resistance and toxicity. This study investigated the potential of Ruta graveolens leaf extracts to overcome EGFR_T790M-mediated resistance in NSCLC. Various polar and non-polar extracts were tested in vitro, with the ethyl acetate extract (EAE) showing the strongest kinase inhibition, especially against the EGFR_T790M mutation. EAE also demonstrated potent cytotoxicity and growth inhibition in EGFR_T790M-positive NSCLC cells, reflected by low IC50 values. Flow cytometry and TUNEL assays confirmed that EAE induced cell cycle arrest and apoptosis in a dose-dependent manner. Mechanistic studies revealed that EAE inhibited EGFR phosphorylation at Tyr1068 and Tyr1173, particularly in H1975 cells. Pull-down assays and mass spectrometry further identified active compounds within EAE. Overall, these findings highlight EAE’s promise as a therapeutic agent against EGFR_T790M-driven lung cancer resistance.

Ethyl acetate is an important material for extracting drugs

Ethyl acetate is colorless transparent liquid, low toxicity, sweet smell, irritating odor at higher concentration, volatile, sensitive to air, can absorb moisture, making it slowly hydrolyzed and acidic reaction. Can be miscible with chloroform, ethanol, acetone and ether, soluble in water (10%ml/ml). Can dissolve some metal salts (such as lithium chloride, cobalt chloride, zinc chloride, iron chloride, etc.) reaction. Relative density 0.902. Melting point -83. Boiling point 77. Refractive index 1.. Flash point 7.2(open cup). Flammable. Vapor can form explosive mixture with air. LD50 (rat, oral) 11.3ml/kg.

SL Tec are exported all over the world and different industries with quality first. Our belief is to provide our customers with more and better high value-added products. Let's create a better future together.

Processed in these plants using top quality ingredients, our offered products are highly miscible with diethyl ether, acetone, ethanol & benzene and are widely used in nail polish remover & glues.

There are 4 main prevailing processes for ethyl acetate production, i.e. Direct Esterification Process, Acetaldehyde Condensation Process, Ethanol Dehydration Process and Acetic Acid-Ethylene Addition Process. Each process has its advantages and its applicable services. Our process is based on reactive-distillation esterification, which is mature, low costing and suitable for those with acetic acid feedstock.

What Is Ethyl Acetate Used For?

These plants are used in various cosmetic, chemical and pharmaceuticals industries for processing and storage of various products.

Applications :

Liquor industry

 Chemical industry

 Pharmaceutical industry

 Paint industry

Further, these plants and machines are designed and developed in different technical specifications, which fit the diverse requirements of the clients. We have gained immense appreciation among our clients for our manufactured and supplied assortment of Ethyl Acetate Plants.

Project of SL Tec Ethyl Acetate Plant

150 tons/day ethyl acetate plant in Turkey

Hubei Sanli Fengxiang Technology Co., Ltd. is responsible for the EPC project of Turkey's 150 tons/day ethyl acetate refined EPC project, including design, procurement, commissioning, operation, training, etc. After experiencing the epidemic and other difficulties, we have successfully produced qualified products and completed the installation load acceptance work. Let us review the progress of the installation.

signing the contract

The contract was officially signed in .

Device Advantages

This device adopts three-tower thermal coupling energy-saving technology, which has the following advantages:

 Energy saving and environmental protection, far below the industry's 1.6t/t steam consumption index;

 Large load operation flexibility of the device;

 High degree of self-control, simple operation;

 Use new catalysts;

 The process route is simple and the investment cost is low.

If you are looking for more details, kindly visit Methyl Methacrylate Plant.

Ethyl acetate - Wikipedia

Organic compound (CH₃CO₂CH₂CH₃) Ethyl ethanoate Names Preferred IUPAC name Ethyl acetate Systematic IUPAC name Ethyl ethanoate Other names

• Acetic ester

• Acetic ether

• Ethyl ester of acetic acid

Identifiers

• 141-78-6 Y

3D model (JSmol) ChEBI

• CHEBI: Y

ChEMBL

• ChEMBL Y

ChemSpider

•  Y

ECHA InfoCard100.005.001  E numberE (additional chemicals) KEGG

• D Y

PubChem CID RTECS number

• AH

UNII

• O8NMZ Y

CompTox Dashboard (EPA)

• InChI=1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3 YKey: XEKOWRVHYACXOJ-UHFFFAOYSA-N Y

• InChI=1/C3H8O2/c1-3-6-4(2)5/h3H2,1-2H3Key: XEKOWRVHYACXOJ-UHFFFAOYAD

• O=C(OCC)C

Properties C4H8O2 Molar mass 88.106 g·mol1   Appearance Colorless liquid Odor nail polish-like, fruity Density 0.902 g/cm3 Melting point 83.6 C (118.5 F; 189.6 K) Boiling point 77.1 C (170.8 F; 350.2 K) 8.3 g/100 mL (at 20 C) Solubility in ethanol, acetone, diethyl ether, benzene Miscible log P0.71[1]Vapor pressure 73 mmHg (9.7 kPa) at 20 C[2]Acidity (pKa) 25 Magnetic susceptibility (χ) 54.10106 cm3/molRefractive index (nD) 1. Viscosity 426 μPa·s (0.426 cP) at 25 C Structure 1.78 D HazardsOccupational safety and health (OHS/OSH): Main hazards

• Flammable (F),

• Irritant (Xi)

GHS labelling:  [3] Danger H225, H319, H336[3] P210, P233, P240, P305+P351+P338, P403+P235[3]NFPA 704 (fire diamond) Flash point 4 C (25 F; 269 K) Explosive limits 2.0–11.5%[2]Lethal dose or concentration (LD, LC): LD50 (median dose) 11.3 g/kg, rat LC50 (median concentration) 16,000 ppm (rat, 6 h)
12,295 ppm (mouse, 2 h)
 ppm (rat, 8 h)[4]LCLo (lowest published) 21 ppm (guinea pig, 1 h)
12,330 ppm (mouse, 3 h)[4]NIOSH (US health exposure limits): PEL (Permissible) TWA 400 ppm ( mg/m3)[2]REL (Recommended) TWA 400 ppm ( mg/m3)[2]IDLH (Immediate danger)  ppm[2]Related compounds Related carboxylate esters Related compounds Supplementary data page Ethyl acetate (data page) Except where otherwise noted, data are given for materials in their standard state (at 25 C [77 F], 100 kPa).Y   (what is YN ?) Chemical compound

Ethyl acetate (systematically ethyl ethanoate, commonly abbreviated EtOAc, ETAC or EA) is the organic compound with the formula CH3CO2CH2CH3, simplified to  C4H8O2. This flammable, colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, and the decaffeination process of tea and coffee. Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent.[5]

Production and synthesis

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Ethyl acetate was first synthesized by the Count de Lauraguais in  by distilling a mixture of ethanol and acetic acid.[6]

In , an estimated 1.3 million tonnes were produced worldwide.[5][7]  The combined annual production in  of Japan, North America, and Europe was about 400,000 tonnes.  The global ethyl acetate market was valued at $3.3 billion in .[8]

Ethyl acetate is synthesized in industry mainly via the classic Fischer esterification reaction of ethanol and acetic acid.  This mixture converts to the ester in about 65% yield at room temperature:

• CH3CO2H  +  CH3CH2OH CH3CO2CH2CH3  +  H2O

The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

It is also prepared in industry using the Tishchenko reaction, by combining two equivalents of acetaldehyde in the presence of an alkoxide catalyst:

• 2 CH3CHO CH3CO2CH2CH3

Silicotungstic acid is used to manufacture ethyl acetate by the alkylation of acetic acid by ethylene:[9]

• C2H4 + CH3CO2H CH3CO2C2H5

Uses

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Ethyl acetate is used primarily as a solvent and diluent, being favored because of its low cost, low toxicity, and agreeable odor.[5] For example, it is commonly used to clean circuit boards and in some nail varnish removers (acetone is also used). Coffee beans and tea leaves are decaffeinated with this solvent.[10] It is also used in paints as an activator or hardener. Ethyl acetate is present in confectionery, perfumes, and fruits. In perfumes it evaporates quickly, leaving the scent of the perfume on the skin.

Ethyl acetate is an asphyxiant for use in insect collecting and study.[11] In a killing jar charged with ethyl acetate, the vapors will kill the collected insect quickly without destroying it. Because it is not hygroscopic, ethyl acetate also keeps the insect soft enough to allow proper mounting suitable for a collection. However, ethyl acetate is regarded as potentially doing damage to insect DNA, making specimens processed this way less than ideal for subsequent DNA sequencing.[12]

Laboratory uses

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In the laboratory, mixtures containing ethyl acetate are commonly used in column chromatography and extractions.[13] Ethyl acetate is rarely selected as a reaction solvent because it is prone to hydrolysis, transesterification, and condensations.

Occurrence in wines

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Ethyl acetate is the most common ester in wine, being the product of the most common volatile organic acid – acetic acid, and the ethyl alcohol generated during the fermentation. The aroma of ethyl acetate is most vivid in younger wines and contributes towards the general perception of "fruitiness" in the wine. Sensitivity varies, with most people having a perception threshold around 120 mg/L. Excessive amounts of ethyl acetate are considered a wine fault.

Reactions

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Ethyl acetate is only weakly Lewis basic, like a typical carboxylic acid ester.

Ethyl acetate hydrolyses to give acetic acid and ethanol. Bases accelerate the hydrolysis, which is subject to the Fischer equilibrium mentioned above.  In the laboratory, and usually for illustrative purposes only, ethyl esters are typically hydrolyzed in a two-step process starting with a stoichiometric amount of a strong base, such as sodium hydroxide. This reaction gives ethanol and sodium acetate, which is unreactive toward ethanol:

• CH3CO2C2H5 + NaOH C2H5OH + CH3CO2Na

In the Claisen condensation, anhydrous ethyl acetate and strong bases react to give ethyl acetoacetate:[14]